Crystal Structure of 4-(1-Mesityl-1-methylcyclobutane-3-yl)-2-(N-ethyl)aminothiazole.

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Crystal structure of 4-(1-mesityl-1-methylcyclobutane-3-yl)-2-(N-ethyl)aminothiazole.

attracted the attention of chemists, since they exhibit important biological activity in medicinal chemistry.1 As one example, they show very good antibacterial effects.2 Here, we report the crystal structure of the title compound, shown in Fig. 1. To a solution of 1.042 g (10 mmol) of N-ethyl thiourea in 50 mL of absolute ethanol, a solution of 2.645 g (10 mmol) of 1-mesityl-1-methyl-3-(2-chrl...

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In the title hydrated salt, C19H24N3 (+)·Br(-)·H2O, the values of the N-C bond lengths within the tetra-hydro-pyrimidinium ring indicate delocalization of the N=C double bond. In the cation, the dihedral angle formed by the pyridine and benzene rings is 14.97 (12)°. In the crystal, ions and water mol-ecules are linked by O-H⋯Br, O-H⋯N, C-H⋯Br and C-H⋯O hydrogen bonds into chains running paralle...

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In the title compound C18H20N2O2, the morpholine ring adopts a chair conformation with the exocyclic N-C bond in an equatorial orientation. The N atom of the morpholine ring and the C atom of the carbonyl group are in an anti conformation about the central C-C bond [torsion angle = -162.92 (11)°] and the dihedral angle between the planes of the benzene ring and the pyridine ring is 83.30 (5)°. ...

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Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

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Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

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ژورنال

عنوان ژورنال: Analytical Sciences

سال: 2002

ISSN: 0910-6340,1348-2246

DOI: 10.2116/analsci.18.725